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buy PB-22 crystal online

$15.00 $10.00

SKU: PB-22 Category:

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buy PB-22 crystal

buy PB-22 crystal   (QUPIC or 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester) is a designer drug offered by online vendors as a cannabimimetic agent, and detected being sold in synthetic cannabis products in Japan in 2013. The structure of PB-22 appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear. PB-22 represents a structurally unique synthetic cannabinoid chemotype, since it contains an ester linker at the indole 3-position, rather than the precedented ketone of JWH-018 and its analogs, or the amide of APICA and its analogs.

PB-22 has an EC50 of 5.1 nM for human CB1 receptors, and 37 nM for human CB2 receptors. PB-22 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity. The magnitude and duration of hypothermia induced in rats by PB-22 was notably greater than JWH-018, AM-2201, UR-144, XLR-11, APICA, or STS-135, with a reduction of body temperature still observable six hours after dosing. One clinical toxicology study found PB-22 to be the cause of seizures in a human and his dog.

PB-22 (Item No. ISO00122) is an analytical reference material categorized as a synthetic cannabinoid. It mimics the effects of Δ9-THC (Item Nos. 12068 | ISO60157).1 PB-22 is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

WARNING This product is not for human or veterinary use.

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